The aim of this special issue is to contribute to the advancement of current knowledge on social stigmatization. Progress in this area has been thwarted by seemingly incompatible findings and unresolved debates. This special issue includes contributions that bear on some of the most important debates in this area. In addition, this issue includes novel perspectives and alternative views to these issues. The issue highlights the social contextual and interactive nature of stigmatization that determines its impact and consequences for those who are stigmatized.