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In this study, a recombinant non-pathogenic Pseudomonas putida KT2440 was applied for rhamnolipid or 3-(3-hydroxyalkanoyloxy)alkanoic acid production....Lees meer
The environmental impact of plastic waste is regularly discussed. With bio-upcycling we can use plastic waste as a substrate for biotechnology. Polyme...Lees meer
In the present thesis, a possible block in the sterol pathway to facilitate 2,3-oxidosqualene accumulation was investigated. Several truncated version...Lees meer
Triterpenoids are plant secondary metabolites with wide application fields. Their production in microbial cell factories is a more advantageous altern...Lees meer
To reduce the demand for fossil resources, biotechnological processes are increasingly applied. Hence, the used biological hosts have to be optimized ...Lees meer
A novel microbial chassis from Paracoccus spp. was developed to support circular bioeconomy goals. A genetic toolbox enabling PET monomer utilization ...Lees meer
This work describes the domestication of Pseudomonas species to produce various aromatic chemicals. The application of rational metabolic engineering ...Lees meer
Reduced, valuable compounds can be produced using metabolically engineered microbes. The production of such molecules often relies on redox-cofactor-d...Lees meer
The life expectancy of liver cirrhosis patients drastically worsens with decompensation. In this work, a clinical score was developed to identify pati...Lees meer
Phosphate (Pi) is essential for all organisms and is typically minds from Pi-rock, which will be depleted in a few hundred years. In this thesis, Pi f...Lees meer
Given the persistent growth in demand for food, energy, and chemicals in the coming decades, a shift from fossil-based raw materials to sustainable al...Lees meer
Methyl ketones with a hydrocarbon chain length of C4 to C17 are currently produced from petrochemical resources, and there is only limited research on...Lees meer
Poly-Gamma-glutamic acid (Gamma-PGA) is a biopolymer with various industrial applications. Despite its diverse applications, Gamma-PGA of defined mole...Lees meer
Building a sustainable society requires moving beyond the linear produce-use-waste model reliant on fossil resources. A circular bioeconomy using CO2-...Lees meer
Ginsenosides are triterpenoids, a class of natural products with many pharmaceutical functions, mainly present in traditional Chinese medicine Panax s...Lees meer
This dissertation advances the use of metabolic models for designing industrially relevant microbial cell factories. At the same time, the presented t...Lees meer
While S. cerevisiae is one of the most used hosts in biotechnology, many aspects of its volatile metabolites are sparsely researched. This works aims ...Lees meer
The burden posed on clinical care and drug development by adverse drug reactions is huge since current prediction methods often fail. In this work, co...Lees meer
Establishing biotechnological processes within the envisaged circular bioeconomy requires the integration of all stages of process development. In thi...Lees meer
Climate change is a pressing global issue that is caused by the consumption of fossil fuels. Cell factories are biological systems that are engineered...Lees meer
This thesis focused on the fungus Ustilago maydis as natural itaconic acid producer. Two strategies were chased to improve its production performance:...Lees meer
Itaconic acid is of growing biotechnological significance due to its use for the production of bio-based polymers, chemicals, and novel fuels. By an i...Lees meer
Aromatics are valuable compounds that are currently produced from non-renewable resources in polluting processes. In this thesis, we engineered solven...Lees meer
Polymalate (PMA), a promising drug delivery system, can be produced by Aureobasidium pullulans NRRL 62031. The key genetic determinant for PMA polymer...Lees meer