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Preface. I: Introduction. 1. Menopause: Epidemiologic Aspects; W.R. Harlan. 2. Coronary Heart Disease in Postmenopausal Women: What we Know and What we Must Learn; N.K. Wenger. II: Introductory Issues. 3. Effects of HRT on Metabolic Risk Factors for Cardiovascular Disease; J.C. Stevenson. 4. Precocious Menopause: a Diagnostic Challenge; R. Rolland. 5. Effect of Ovarian Failure on Target Tissues; G. Samsioe. 6. Epidemiology of Cancer in Women; P. Boyle, T. Evstifeeva, L. Luchini. 7. Breast Cancer Risk in Hormone Replacement Therapy-Treated Women; C. La Vecchia. III: Estrogen Replacement Therapy and Cardiovascular Disease. 8. Benefits of Different Routes of Administration; M.H. Birkhäuser, W. Hänggi. 9. Atherosclerosis and Estrogen Replacement Therapy; J.M. Sullivan. 10. Cardiovascular Protection by Estrogen: a Hemodynamic Mechanism? S. Rozenberg, I. Liebens, J. Vandromme, A. Hotimsky, M. Van Rijsselberge. IV: Prophylactic Oophorectomy: a Debate. 11. Prophylactic Oophorectomy: Risks and Adverse Effects Outweigh Potential Benefits; G. Samsioe. 12. The Arguments in Favor of Prophylactic Oophorectomy at Hysterectomy; J. Studd, R. Sands. V: Behavior and Lifestyle in Perimenopausal Years. 13. Hypophysiotropic Peptides and Aging; D. Cocchi, E.E. Muller. 14. Psychosocial Factors Influencing Experience of the Menopause and Help-Seeking Behavior; M.S. Hunter. VI: Cardiovascular Disease and Hormone Replacement. 15. Lipoprotein(a) Changes in Perimenopausal Years; M. Meschia, F.Bruschi, M. Soma, F. Amicarelli, R. Paoletti, P. Crosignani. 16. Epidemiologic Studies on ERT and Cardioprotection: State of the Art on HRT and Cardiovascular Disease; F. Grodstein, M.J. Stampfer. 17. Vasoactive Effects of Estrogens; P.M. Sarrel. 18. HRT and Correction of Lipoprotein Disorders; C.R. Sirtori, M.R. Soma. 19. Menopause, Thrombosis, and Hormone Replacement Therapy; V.V. Kakkar. VIII: Menopause Management: Extensive Clinical Experience and Benefits of Natural Conjugated Estrogens. 20. Effects of Conjugated Estrogen Therapy: Medrogestone and Lipidic Metabolism; M.H. Birkhäuser, W. Hänggi. 21. Ovarian Hormones and Arterial Function; P.M. Sarrel. 22. Hormone Replacement Therapy and Gynecologic Cancers; P. Sismondi, N. Biglia, E. De Fabiani, L. Sgro, A. Sandri, C. Campagnoli. VIII: Hormone Replacement Therapy: Improved Quality of Life. 23. From Contraception to Menopause; R.J.E. Kirkman. 24. Choice of a Preparate in HRT. Clinical Aspects with Estradiol Valerate/Cyproterone Acetate; M. Oliveira da Silva. 25. Estrogens Modulation of Neuroendocrine Functions in Postmenopause; A.D. Genazzani, M. Gastaldi, A. Gallinelli, E. Esposito, F. Petraglia, A.R. Genazzani. IX: Prevention and Therapy (CNS, Connective Tissues, and Osteoporosis). 26. Estrogens and Depression in Women; J. Studd. 27. Estrogen Deficiency and Connective Tissues; M. Brincat, Y. Muscat Baron, R. Galea, A. Buhagiar. 28. Urinary Dysfunction and the Climacteric; C. Kelleher, L. Cardozo. Index.