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Synthesis and Biological Screening of some Sulfonamides & Oxadiazoles
Synthesis of Some Sulfonamides & 1,3,4-Oxadiazoles
Aziz-ur- Rehman
Paperback | Engels
€ 39,45
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Omschrijving
In the present study, various N-alkyl substituted derivatives of benzene-sulfonamide were synthesized. In the first step, benzene sulfonyl chloride was treated with 2-amino-2-methyl-1-propanol afforded N-(2-hydroxy-1,1-dimethylethyl)-benzenesulfonamide and in next step this parent compound was reacted with alphatic halides to produced different N-alkylation substituted derivatives. Oxadiazole are very important compounds that are strongly biologically active. In this study the parent compound 5-benzyl-1,3,4 oxadiazole-2-thiole was synthesized by hydrazinolysis of ethyl phenylacetate followed by reaction with carbon disulfide. Further the parent compound oxadiazole was treated with different aliphatic alkyl groups to produce eight different S-substituted derivatives of oxadiazole. All these synthesized derivatives of sulfonamides and oxadiazoles were characterized by melting point, IR, EI-MS, 1H-NMR and X-ray crystallographic techniques. These compounds were screened.to evaluate their biological activity and only sulfonamides showed inhibition potentials against butyrylcholinesterase.
Specificaties
Betrokkenen
- Auteur(s):
- Uitgeverij:
Inhoud
- Aantal bladzijden:
- 64
- Taal:
- Engels
Eigenschappen
- Productcode (EAN):
- 9783659285721
- Verschijningsdatum:
- 27/03/2014
- Uitvoering:
- Paperback
- Afmetingen:
- 150 mm x 220 mm
- Gewicht:
- 104 g
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