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Medicina Gymnastica: Or, a Treatise Concerning the Power of Exercise, with Respect to the Animal Oeconomy; and the Great Necessity of it in the Cure of Several Distempers is a seminal work by Francis Fuller, first published in 1704, that explores the profound impact of physical exercise on human health and well-being. Drawing from both classical sources and contemporary medical observations, Fuller presents a comprehensive argument for the therapeutic value of exercise, positioning it as an essential component in the maintenance of health and the treatment of a wide range of ailments. The book delves into the physiological mechanisms by which exercise influences the animal oeconomy—the body's internal systems and functions—emphasizing the importance of movement in promoting circulation, digestion, and the expulsion of harmful humors. Fuller systematically examines various forms of exercise, from walking and riding to more vigorous activities, and discusses their specific benefits and potential risks. He provides detailed guidance on the appropriate types and amounts of exercise for individuals of different ages, constitutions, and health conditions, advocating for a personalized approach to physical activity. In addition to its practical advice, Medicina Gymnastica offers a critical perspective on the prevailing medical practices of the time, challenging the overreliance on drugs and passive treatments. Fuller argues that many chronic and acute diseases—such as gout, melancholy, and digestive disorders—can be effectively managed or even cured through regular, moderate exercise. He supports his claims with case studies, anecdotes, and references to ancient authorities like Hippocrates and Galen, blending empirical evidence with philosophical reflection. The treatise also addresses the social and cultural dimensions of exercise, lamenting the sedentary lifestyles of the upper classes and urging a return to more active habits. Fuller’s work is notable for its accessible style, making complex medical concepts understandable to a broad audience, and for its enduring relevance in the ongoing discourse on preventive medicine and holistic health. Medicina Gymnastica stands as a pioneering text in the history of sports medicine and physical therapy, anticipating many modern insights into the relationship between exercise and health. It remains a valuable resource for historians, medical professionals, and anyone interested in the origins of exercise science and the evolution of health practices.