
The novel begins in Marseilles "thirty years ago" (c. 1826), with the notorious murderer Rigaud telling his cellmate John Baptiste Cavalletto how he killed his wife. Arthur Clennam is detained in Marseilles with a group of travellers in quarantine. He meets new friends in the quarantine. He is returning to London to see his mother after 20 years in China with his father, handling that part of the family business. His father died there. On his deathbed, his father had given him a mysterious message, murmuring "Your mother," which message and a watch Arthur mails to Mrs Clennam.
Inside the watch casing is an old silk paper with the initials DNF (Do Not Forget) worked in beads. It is a message, but the implacable Mrs Clennam, who now uses a wheelchair, refuses to tell him what it means. The two become estranged.
The novel was originally published in monthly instalments in the magazine Bentley's Miscellany, from February 1837 to April 1839. It was originally intended to form part of Dickens's serial, The Mudfog Papers. George Cruikshank provided one steel etching per month to illustrate each instalment. The novel first appeared in book form six months before the initial serialisation was completed, in three volumes published by Richard Bentley, the owner of Bentley's Miscellany, under the author's pseudonym, "Boz". It included 24 steel-engraved plates by Cruikshank.
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