Afhalen na 1 uur in een winkel met voorraad
Gratis thuislevering in België vanaf € 30
Ruim aanbod met 7 miljoen producten

Afhalen na 1 uur in een winkel met voorraad
Gratis thuislevering in België vanaf € 30
Ruim aanbod met 7 miljoen producten

Winkels

Verlanglijstje

Winkels

Verlanglijstje

Zoeken

Volg ons op

140 winkels

Wist je dat er in Vlaanderen voor iedereen een Standaard Boekhandel is binnen een straal van 7 km?

Vind hier een winkel

€ 49,45

+ 98 punten

Levertermijn 1 à 4 weken

Eenvoudig bestellen

Veilig betalen

Gratis thuislevering vanaf € 30 (via bpost)

Gratis levering in je Standaard Boekhandel

Omschrijving

Eosinophils are known for their role as anti-helminthic agents & as inflammatory effectors in allergic hypersensitivity &bronchial asthma. Their granules contain extremely cytotoxic proteins which are responsible for damage to the normal epithelia, & contribute to allergic responses & the onset of asthma. Preliminary observations had shown tumor cell growth was inhibited by a crude eosinophil protein extract & partially inhibited by IL-4 & TNF- ; also produced by eosinophils. Characterization of the protein isolated from the granules confirmed its identity as that of the eosinophil major basic protein as demonstrated by silver stain & western blot. The growth of both cancer cell lines was significantly inhibited by the protein isolate alone & in combination with select inflammatory & non-inflammatory cytokines. Additional results showed that the combination of protein isolate and selected cytokines differentially down-regulated the expression of oncogenes in the cell lines. The results demonstrate the functional potency of this eosinophil granular mediator in inhibiting in vitro tumor cell growth & suggest an effector role for this cell in the host response against breast cancer.