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In order to investigate work-related back injuries, researchers need efficient, accurate occupational exposure assessment methods suitable for large samples. This book examines critical decisions for measuring physical workload: How should exposure be measured? For what duration? Who should be measured, and how many times? To answer these questions, low-back electromyography (EMG) was collected during 138 full-shift field measurements over 30 different job titles at 50 different worksites in 5 heavy industries: forestry, transportation, wood products, construction, and warehousing. Observations and self-reports of working exposures were collected concurrently. Among the results emerges a theme of optimizing the choices for study design and sampling strategy. The ubiquitous constraints of budget and access to industrial populations require tradeoffs between using a highly accurate exposure assessment method on a few people or a less precise method on a larger number of people, between measurement duration and sample size, and between measuring many individuals or repeats within individuals. The results presented help inform risk guidelines, policy, and efforts to control exposure.